Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract Pycnogenol® dose-dependently lowers glucose in type 2 diabetic patients. Pycnogenol®, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. 22. Pycnogenol® improves left ventricular function in streptozotocin-induced diabetic cardiomyopathy in rats. 60. 35. These patients were evaluated clinically by parameters such as the melasma area index, pigmentary intensity index and by routine blood and urine tests. Five major molecular mechanisms contribute substantially to aging and chronic diseases.Studies show that Pycnogenol® combats all five mechanisms and prevents disease. For some, however, pyncogenol is actually an allergen. Panminerva Med. 2015 Mar;144:94-103. doi: 10.1016/j.jphotobiol.2014.12.025. Here's what you should know before taking it. I was hoping to get Fraxel laser but now read that it can make melasma worse. Menopause in women also causes loss of memory and some other brain functions. 54. The clinical cases listed below are hyperpigmentation cases treated by certified dermatologists and healthcare professionals. Melasma Food Chem Toxicol. Effects of Pycnogenol® on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. It reduces their “stickiness,” which lowers the risk that these tiny blood cells will produce a deadly clot in one of your vessels.28, Smokers, who are at high risk for blood clots, participated in a study that showed 200 mg of Pycnogenol® was sufficient to reduce over-activated platelet function.32 This effect is likely due to reduction in thromboxane, a clot-inducing protein that is elevated in many high-risk conditions including diabetes and obesity.33. The multiple anti-aging mechanisms of Pycnogenol® would be expected to substantively reduce risk for cardiovascular disease, diabetes, cognitive decline, and arthritis. J Cardiovasc Pharmacol. Joints age for the same reason that other tissues do; they succumb to the 5 basic mechanisms of aging that we've been discussing. People with diabetes are in a constant state of accelerated aging, vulnerable to all five of the key mechanisms described on the preceding page. Learn more . Angiology. 15. Other symptoms also decreased during the 30 days, … Grether-Beck S, Marini A, Jaenicke T, Krutmann J. Within 1 week of stopping Obagi and moving on to my new melasma obsession Lumixyl the melasma came back 100% + 10% and that means more melasma. the melasma area index, which was based on assessing the diameter of the lesional skin area by means of a ruler. Type II diabetics taking Metformin® along with 100 mg per day of Pycnogenol® demonstrated a decrease in blood sugar of over 16%.65. Hasegawa N, Mochizuki M. Improved effect of Pycnogenol® on impaired spatial memory function in partial androgen deficiency rat model. Protective effects of Pycnogenol® on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats. Segger D, Schonlau F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. 10. Pycnogenol® reduces DNA damage by its antioxidant effect and possibly other mechanisms. 2010 Jul 30;186(2):219-27. J Ocul Pharmacol Ther. Phytother Res. Diabetes Res Clin Pract. 59. 2002 Apr;40(4):158-68. Liu FJ, Zhang YX, Lau BH. bought 50 mg capsules of a supplement : Pycnogenol . Before supplementation, patients could walk only about 223 feet; that distance increased 66% to 650 feet after treatment. 12. Pycnogenol® has been shown in numerous scientific studies to significantly lower blood sugar levels and mitigate the effects of elevated blood sugar on the body.6,35,36,41,43,65,66 In a double-blind, randomized, placebo controlled study of 77 individuals diagnosed with type II diabetes who were also using metformin, 100 mg per day of Pycnogenol® was shown to significantly lower fasting blood sugar by 16.2% in just 8 weeks.65, Figure 5: Pycnogenol® has been shown to enhance the blood sugar lowering effects of Metformin®. Over time, the other aging mechanisms also accumulate in the brain, eventually leading to loss of memory, slowed learning, and specific conditions like Alzheimer's disease. Pycnogenol® also stimulates cells to take up excess glucose from the blood, reducing blood sugar even more.38,39 Patients treated with 125 mg/day of Pycnogenol® saw a drop in fasting blood sugar of 23.7 mg/dL, compared with a decrease of just 5.7 in controls. 32. Krizková L, Chovanová Z, Duracková Z, Krajcovic J. Antimutagenic in vitro activity of plant polyphenols: Pycnogenol® and Ginkgo biloba extract (EGb 761). Take supplements of anti-oxidant such as Pycnogenol tablets 25 mg with meals 3 times daily can enhance results of any melasma treatment. Int J Clin Pharmacol Ther. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). 2009 Jun;23(6):840-3. Premium Questions. Belcaro G, Cesarone MR, Errichi S, et al. Ryan J, Croft K, Mori T, et al. Pycnogenol, but not placebo, augmented FBF response to ACh, from 13.1 +/- 7.0 to 18.5 +/- 4.0 mL/min per 100 mL tissue (p. 0.05). Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. Before & After results. Phytother Res. 55. 65. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. bought 50 mg capsules of a supplement : Pycnogenol. ... Have had Melasma on face. Studies show that Pycnogenol® synergistically attacks five of the most prominent causes of aging in skin and in many other organs and systems. Clin Appl Thromb Hemost. Pycnogenol® reduces skin aging, prevents wrinkling and abnormal pigment deposits, and even reduces skin symptoms of cardiovascular disease. Chem Biol Interact. A malfunctioning endothelium can't properly control blood flow and pressure. These effects were most pronounced in women presenting with dry skin conditions prior to the start of supplementation. This site needs JavaScript to work properly. Biol Pharm Bull. Belcaro G, Cesarone MR, Errichi BM, et al. Male fertility support. Fitoterapia. 9. Among the most exciting developments with Pycnogenol® and nitric oxide are studies showing that Pycnogenol® can mitigate the effects of congestive heart failure. Ratings based on results of the 2020 ConsumerLab.com survey of supplement users. The incidence of type II diabetes is skyrocketing in many countries worldwide.67 Chronically elevated blood sugar causes debilitating damage to just about every bodily system. Figure 2: After 6 weeks supplementation with a Pycnogenol®–containing supplement, skin elasticity improved by 9% over the placebo group.14. Res Pharm Sci. 2009 Oct;20(7):567-75. Would you like email updates of new search results? When platelets are overactive, clots form inside blood vessels, blocking blood flow. Pycnogenol (pine bark extract) is promoted as a treatment for everything from ADHD to arthritis, and it's become a top-selling supplement. Gynecol Endocrinol. The results confirmed that Pycnogenol can help increase elasticity and also demonstrated that Pycnogenol can help reduce skin fatigue. 2002 Jul 15;104(1):55-65. Pycnogenol® (pronounced pic-NOJ-en-all) is the trade name for an extract of French Maritime Pine Bark (Pinus pinaster). The general effective rate was 80%. Numerous studies have shown that Pycnogenol® can reduce many of the aging factors that destroy supple skin by reducing free radical damage and protecting collagen and elastin from enzymatic degradation. According to the Memorial Sloan-Kettering Cancer Center, pycnogenol also shows effectiveness in treating allergies, and some people take it before the onset of allergy season. Epub 2015 Jan 6. Pycnogenol enhances NO (nitric oxide) production which leads to an improvement in blood vessel dilation and an increase in blood flow and oxygen supply to muscles. I often write about treatments for melasma. 1998 Oct;32(4):509-15. HHS Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol®. J Dermatolog Treat. 2012 Feb 15;52(4):765-74. Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. 51. Melasma before after pictures provided by Q Esthetics Laser Clinic, contact us to see more amazing before after photos of laser melasma treatment. Before, during and after supplementation, their skin condition was assessed (i) by employing non-invasive, biophysical methods including corneometry, cutometry, visioscan and ultrasound analyses and (ii) by taking biopsies and subsequent PCR for gene expression analyses related to extracellular matrix homeostasis. Errichi S, Bottari A, Belcaro G, Cesarone MR, Hosoi M, Cornelli U, Dugall M, Ledda A, Feragalli B. Panminerva Med. The benefits of Pycnogenol for skin are actually quite substantial to the point where I’m surprised that I hadn’t heard of this product sooner. By 12 weeks of treatment, their skin roughness was reduced by 6%. 3. As little as 50 mg per day of Pycnogenol® had significant blood sugar lowering effects not just on fasting blood sugar but post-meal blood sugar as well. In addition to the sun damage, I also have spots of melasma, due to taking birth control. More information at www.ConsumerLab.com/survey. Let's first examine Pycnogenol's® impact on preserving and restoring skin health and vitality before we turn to its internal health benefits. Available at: http://www.cdc.gov/arthritis/basics/osteoarthritis.htm. Pycnogenol® supplementation lowers blood sugar levels, especially in the critical after-meal period when high sugar leads most powerfully to heart disease.35,36 One way Pycnogenol® works is by blocking starch breakdown in the intestine.37 This slows glucose absorption (we get much of our glucose from breaking down starch), and helps level off the blood sugar flux throughout the day. 50 mg pycnogenol – 2 x day 15 drops of grapefruit seed extract – 3 x day 50 mg zinc – 1 x day ... It’s excellent. Known as melasma, or chloasma, it’s most common in pregnancy but the contraceptive pill can also cause hyperpigmentation. 2011 Sep;53(3 Suppl 1):75-82. Because of its astringent taste and occasional minor stomach discomfort, it may be best to take Pycnogenol® with or after meals. It took a couple weeks, but I am cautiously optimistic. 2006 Oct;12(4):440-4. Pycnogenol is a dietary supplement that is used to help a whole host of health needs but as a side effect, it was discovered that it also had some pretty powerful anti-aging qualities too. Enseleit F, Sudano I, Periat D, et al. These effects are most likely due to an increased synthesis of extracellular matrix molecules such as hyaluronic acid and possibly collagen. Pycnogenol®, a natural mixture of health-promoting phyto-molecules, dramatically improves skin aging, reducing the risk of wrinkles, abnormal pigmentation, and even the thinning and ulceration that accompanies vascular insufficiency. Cesarone MR, Belcaro G, Rohdewald P, et al. 2004 Feb;79(2):193-8. Free Radic Res. 25. Where: This is water-based so apply after cleansing and before anhydrous, oils or creams. Liu F, Lau BH, Peng Q, Shah V. Pycnogenol® protects vascular endothelial cells from beta-amyloid-induced injury. LDL (bad) cholesterol dropped by 12.7 mg/dL as well.6 In a second study involving 30 individuals with type II diabetes who were not on conventional therapy, Pycnogenol® showed dose dependent lowering of blood sugar levels.35 The participants were administered 50 mg of Pycnogenol® for 3 weeks, followed by 100 mg for 3 weeks, and finally 200 mg for 3 additional weeks. Supplementing animals with Pycnogenol® reverses that remodeling in congestive heart failure, reduces the gradual degradation of heart muscle proteins, and restores the heart's ability to pump blood normally.30,31, Boosting nitric oxide in endothelial cells and platelets also gives Pycnogenol® impressive effects on platelet function. Pycnogenol® also helps improve spatial memory in aged animals with low testosterone (a common finding in men after "male menopause").48 Spatial memory is what you use to remember where you put something, for example. 2008 Mar-Apr;20(2):173-80. Conclusion: 50 mg pycnogenol was shown to be effective in the treatment of melasma after use of 2 tablets / day for 90 days. Some of the images you are going to see aren’t just hyperpigmentation but also meladerm pigment cream works on melasma, fine lines, age spots as well as providing healthy skin benefits. Errichi S, Bottari A, Belcaro G, et al. I've been asked if taking pycnogenol shows any promise in treating this condition or at least in making it look somewhat better. Read more about pigmentation and melasma and the best The Ordinary & Deciem products to use. NLM Nishioka K, Hidaka T, Nakamura S, et al. Kim YJ, Kim YA, Yokozawa T. Pycnogenol® modulates apoptosis by suppressing oxidative stress and inflammation in high glucose-treated renal tubular cells. 18. More than skin deep, these degradations also are reflective of our internal aging as well. If you do have melasma, it would be best to speak to a dermatologist if it is at all possible. Ni Z, Mu Y, Gulati O. Prevention and treatment information (HHS). Buy Now. Rohdewald P. Pycnogenol® protects DNA against oxidative damage in vivo. Cesarone MR, Belcaro G, Rohdewald P, et al. A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins. 2008 Jul;22(5):553-62. 34. An independent study at a different hospital showed similar results.41 Eighteen out of 24 patients had subjective improvement in their vision, and the average visual acuity on the Snellen chart improved by 21.4% after just 2 months of treatment. Chovanova Z, Muchova J, Sivonova M, et al. That’s after being awake for virtually an entire 24 hours. In animal studies, mice supplemented with a mixture containing Pycnogenol® had significantly fewer wrinkles after exposure to UV light.13 They also had reduced UV-induced skin thickening and toughening, problems that also age human skin. I had used diluted P50W for sensitive skin the night after the facial. Treatment of osteoarthritis with Pycnogenol®. Cardiovasc Toxicol. Diabetic damage to capillaries in the skin (microangiopathy) produces skin breakdown and ulcers. 2000 Mar 21;2(2):73-7. 5. Strict control of blood sugar and weight loss will reduce, but not eliminate, the risk of diabetic complications. Hypertens Res. Placebo recipients saw little change. My own research and talking with a friend, Dr. Michael Traub, informed me that what I had was called Melasma – a hyperpigmentation of the skin due to hormonal changes and sun exposure. Schäfer A, Högger P. Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol®) effectively inhibit alpha-glucosidase. What is melasma? Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract. Conclusion: 50 mg pycnogenol was shown to be effective in the treatment of melasma after use of 2 tablets / day for 90 days. Ansari MA, Keller JN, Scheff SW. 62. Chronic venous insufficiency, unlike wrinkling and melasma, is often part of a life-threatening process, such as congestive heart failure or a blood clot.16 The resulting skin breakdown and ulceration also opens victims up to the risk of serious infections.
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