A WOLF clothing himself in the skin of a Sheep, and getting in among the flock, by this means took the opportunity to devour many of them. 0000026599 00000 n 0000050368 00000 n Extensive experimental evidence shows that platelets support tumour metastasis. to no metastasis in the absence of platelets, and this is reversed by additional depletion, reactivity may be crucial for the metastasis-, influencing platelet-tumor-NK cell inter-, class I was in fact transferred to the tumor, dition, while responses to tumor cells that, phenotype of false pretenses: the transfer, It should be noted that beyond prevention, by platelets and certainly also influence, consider that platelets may also influence, *Correspondence to: Helmut R. Salih; Email: Helmut.Salih@med.uni-tuebingen.de, the reactivity of NK cells by soluble factors, that are released upon tumor cell-platelet, explain discrepancies between our results. A total of 530 patients were included and randomly divided into derivation (n = 265) and validation cohort (n = 265). Pulmonary metastases with CT26 cells could be inhibited by induction of thrombocytopenia, and reconstituted by infusion of either murine or human platelets. Abstract. ... A direct surface platelet interaction with tumor cells has been previously described where P-selectin bearing platelets bind to a large number of tumor cells [29][30][31], aiding their leak in the circulation during the metastatic process and subsequently in the attachment to the endothelium. Here, we discuss the mechanisms by which platelets contribute to immunity: these small cells are more immunologically savvy than we once thought. 0000001405 00000 n Edgardo Lander. �4�zz� ˩ ���. Tumor engraftment can also be stimulated by the pro-angiogenetic potentials of platelet growth factors released by PMPs. Wolf In Sheeps Clothing Intro tab by Set It Off feat. An exposé of the lies and deception spun by 60's radical, Saul Alinsky. The Edwards Plateau itself encompasses about 24 million acres of “Hill Country” in West-Central Texas comprising all or portions of 37 counties (Fig. an Aesop fable. 109 views, added to favorites 3 times. Metastasis is strongly inhibited in thrombocytopenic mice. Policy briefing. Solo. 0000039586 00000 n A creature that eats a carcass used by the monster as a corpse lure automatically becomes implanted. Nat Rev Immunol 6(10): 715-727, Platelet-Derived MHC Class I Confers a Pseudonormal Phenotype to Cancer Cells That Subverts the Antitumor Reactivity of Natural Killer Immune Cells, Modulation of Natural Killer Cell Anti-Tumor Reactivity by Platelets, Gay LJ, Felding-Habermann BContribution of platelets to tumour metastasis. One hundred and ninety-six patients met the inclusion criteria. High platelet count (H-PC) was found in 32%, and it was associated with a higher rate of palliative surgery (p < 0.001), extra-hepatic metastases (p < 0.001), bilobar liver disease (p = 0.007), presence of more than three metastases (p = 0.005), biggest metastasis larger than 5 cm (p < 0.001), and CEA level higher than 200 ng/mL (p = 0.035). Platelet-adhesive protein-tumor cell interaction was studied in vitro and in vivo. (C) Transfer of platelet MHC Class I results in a, without inducing T cell reactivity due to presentation of. A wolf-in-sheep’s-clothing can infest a creature with its eggs in one of two ways. The prognosis of intrahepatic cholangiocarcinoma (ICC) patients following surgical resection remains poor. These results were observed in the training cohort and were confirmed in the validation cohort. © 2008-2021 ResearchGate GmbH. Readily available at local bookstores, libraries (if they don’t have it in stock, please ask and they’ll order it! This clue was last seen on January 15 2021 on New York Times’s Crossword. The story of Saul Alinsky, the father of community organizing, and the rise of his Cultural Marxism in the Catholic Church and America. Maeve Kiely 1 and Patrick A. Kiely 1,2, * 1 Department of Life Sciences, and Materials and Surface Science Institute, University of Limerick, 0000005612 00000 n Manny’s reading this book In Sheep’s Clothing Understanding and Dealing with Manipulative People and I’m thinking he’s going to start applying it to goodreads, isn’t he? In Sheep’s Clothing (1996) analyzes the psychology of power-obsessed individuals, manipulative people, and covert-aggressive men. In this study, we show that tumor cells rapidly get coated in the presence of platelets in vitro, and circulating tumor cells of cancer patients display coexpression of platelet markers. Wolf in sheep’s clothing . Paradoxically, the emergence of Human Resource Management (HRM) represents both a challenge and an opportunity to the practice of personnel management. Conclusion: 0000036938 00000 n If you have any other question or need extra help, please feel free to … 0000004888 00000 n Wolf In Sheeps Clothing Intro tab by Set It Off feat. Directed by Stephen Payne. In the end the sheep does fool others and has them as a meal. At the multivariate analysis on R0-1 cases, platelet count resulted the only independent predictor of survival (HR 2.07, p = 0.036). Once upon a time, there was a certain Wolf who could not get enough Sheep to eat because of strict monitoring of The Shepherds. NK cells are now recognized to express a repertoire Purpose Wolf In Sheep's Clothing trumpet part . Conclusion The Wolf in Sheep's clothing is about cutting two face or fair weather friends out of your life. %PDF-1.5 %���� Platelets physically and functionally interact with various tumor cells through surface receptors including integrins. They are also involved in non-hemostatic function such as development, immunity, inflammation, and in the hematogeneous phase of metastasis. The intimate PMP-tumors crosstalk may therefore result in pro-thrombotic states and a physiological state favourable to tumor growth, tethering and dissemination. Translators. >V��$;� #�J�S�t���@G|�V�$K��x�#JE #v�F��:�DKAǙ~X!�I����u�������d�s9�A9�H��� Platelets are small anucleated cell fragments that ensure the arrest of bleeding after a vessel wall injury. Platelet-derived MHC Class I, confers a pseudo- normal phenotype to cancer cells that, subverts the anti-tumor reactivity of natural killer. Science, 2011; 331:44-9; PMID:21212348; http://dx.doi.org/. The inventory and distribution of sheep and goats by counties in 2003 is reflected in Figures 1 and 2. 0000051039 00000 n The possible detrimental effect of transfusions in cancer patients has been debated for several years and the role played by PMPs present in blood products is receiving specific attention, considering their propensity to trigger thrombosis and support tumors. "You too can become a hero!" Recently, deposition of plasma fibronectin, and likely other plasma proteins, onto the injured vessel wall has been identified as a new "protein wave of hemostasis" that may occur even earlier than the first wave of hemostasis, platelet accumulation. Nat Rev, Immunol 2007; 7:329-39; PMID:17438573; http://. (B) MHC Class I downregulation enables escape from, recognition. Low platelet counts in blood caused by enhanced platelet clearance and/or impaired platelet production are usually associated with hemorrhage. This may lead to myocardial infarction or ischemic stroke, the major causes of mortality and morbidity worldwide. Look at the picture and try to guess the meaning of the idiom 'a wolf in sheep's clothing.' 0000053681 00000 n Resources. Patients with increased SII level were associated with worse OS and earlier tumor recurrence. Directed by Stephen Payne. A wolf in sheep's clothing is an idiom of Biblical origin used to describe those playing a role contrary to their real character with whom contact is dangerous, particularly false teachers. Last edit on Mar 27, 2020. Much later, the idiom has been applied by zoologists to varying kinds of predatory behaviour. An analysis of the ‘sustainable intensification’ of agriculture Introduction Knowledge Science and Technology for Development, has said: ‘business as usual is not an option’.11 The need for dramatic change in the food system is increasingly evident … Description. Monospecific polyclonal antifibronectin antibody inhibited binding by 60-82%; anti-von Willebrand factor antibody inhibited binding by 75-81%. Summary: A single moment. In conclusion, patients with a simultaneously high SIRI-PLR value had significantly poor prognosis. They do say the best cover story is one that’s close to the truth… The Wolf in Sheep's Clothing A Wolf found great difficulty in getting at the sheep owing to the vigilance of the shepherd and his dogs. NK cells, platelets, thrombocytes, cancer, metastasis, MHC Class I, tumor immunosurvei, MHC, major histocompatibility complex; NK, natural killer; TGF, transforming growth factor, s own MHC Class I; the latter at the same time inhibits NK cell reactivity. The main role of platelet integrins is to ensure platelet adhesion and aggregation at sites of vascular injury. The permanent success of treatments for cancer might depend on using immunogenic chemotherapy to re-establish antitumour immune responses. The Eagle and the Jackdaw. For with the judgment you pronounce you will be judged, and with the measure you use it will be measured to you. His political tactics and theories espoused social justice, but carried an agenda that threatened core beliefs of Christianity and the Church. A certain Wolf could not get enough to eat because of the watchfulness of the Shepherds. Platelet Microparticles and Cancer: An intimate cross-talk, Association of preoperative systemic Immune-inflammation Index and Prognostic Nutritional Index with survival in patients with Upper Tract Urothelial Carcinoma, Combination of Systemic Inflammation Response Index and Platelet-to-Lymphocyte Ratio as a Novel Prognostic Marker of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy, Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection, Prognostic value of thrombocytosis in patients undergoing surgery for colorectal cancer with synchronous liver metastases. hashtagstone. Available via license: CC BY-NC 3.0. subversion. At a median follow-up of 18 mo (range, 1-115.4 mo), 317 (59.8%) patients died and 381 (71.9%) patients experienced tumor relapse. 0000005852 00000 n Dysfunctional platelets play key pathological roles in thrombosis and bleeding disorders. … Monoclonal antibody 10E5, which inhibits binding of fibronectin and von Willebrand factor to the platelet membrane glycoprotein GPIIb-GPIIIa complex, inhibited the binding of mouse CT26 and human HCT8 colon carcinoma cells to platelets by 63-65%, whereas an irrelevant monoclonal antibody, 3B2, had no effect. Here, we review evidence for the role of NK cells in immune surveillance against cancer and highlight new therapeutic approaches for targeting NK cells in the treatment of cancer. Laboratory and experimental studies are needed to better unveil the contribution of PMPs as coagulation promoters, as well as a potential marker and targets to treat cancer. The Wolf in Sheep's clothing - transcript to print/download. The wolf in sheep’s clothing.pdf. More recently, a more nuanced view of NK cells has emerged. HRM: A Case of the Wolf in Sheep’s Clothing? Brenda is the star of a new illustrated children’s book. The sheep were just a little stupid. Read The Brigade A Wolf In Sheeps Clothing PDF on our digital library. — Luckily I realized years ago that my mother-in-law was a wolf in sheep's clothing —she's nice but always highlights my faults and tells the family about every mistake I make. Metastasis is strongly inhibited in thrombocytopenic mice. In particular, a simultaneously high SIRI-PLR value was considered an independent risk factor even after adjusting for confounding factors and was superior to SIRI alone in predicting survival among patients with UTUC. Wolf in Sheep s Clothing. Platelets are critical physiological mediators of vascular repair and hemostasis through surveillance of the vascular endothelium, adhesion and aggregation at sites of injury, and participation in the coagulation cascade. While the interaction of NK cells e.g. In mice, metastasis is inhibited by thrombocytopenia, and this effect is reversed by additional NK cell depletion, indicating that platelets may 'indirectly' contribute to tumor dissemination by impairing NK cell anti-tumor reactivity. But one night he found a sheep skin that had been cast aside and forgotten. On this page you will find the solution to “The Wolf in Sheep’s Clothing ” for one crossword clue crossword clue. trailer <<1C4BCF06862140A6AFD8EA4131CA01FA>]/Prev 98853>> startxref 0 %%EOF 50 0 obj <>stream Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond, The Platelet as a Physiological Object in the Circulation, The Prognostic Significance of the Preoperative Platelet-Lymphocyte Ratio in Japanese Patients with Localized Breast Cancer, NK cells and cancer: You can teach innate cells new tricks, Innate or Adaptive Immunity? This phenotype is reversed by NK cell depletion which. 0000036869 00000 n Buy DVD. Who they present themselves to be is far different from who they truly are. Conventional personnel management is being out‐moded to be superseded by an … The story of Saul Alinsky, the father of community organizing, and the rise of his Cultural Marxism in the Catholic Church and America. Access scientific knowledge from anywhere. Definitions by the largest Idiom Dictionary. He spent his time spying on the sheep in Farmer Foggarty s field… and thinking of wily ways to catch them. Apart from the direct interaction with their targets, NK cell activity is influenced by the reciprocal interplay with other hematopoietic cells. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. On this page you will find the solution to “The Wolf in Sheep’s Clothing ” for one crossword clue crossword clue. Publisher: Carina Press. Author : Tommy McIntyre File Size : 88.47 MB Format : PDF, ePub, Mobi Download : 815 Read : 964 . Receiver-operating characteristic (ROC) curves were used to determine the optimal cut-off values of SII. Read 294 reviews from the world's largest community for readers. 1 Lyrics 2 Other Appearances 3 Videos 3.1 Official 3.2 Covers The song was featured on the album Duality. the immune continuum. By the 1920s, many of the interior Edwards Plateau counties were considered to be free of coyotes and wolves. In the future, the SII could help stratifying patients with ICC, thus guiding therapeutic choices, especially in immunotherapy. immunosurveillance: immunoselection and immuno-. Results Here, we review the available data regarding tumor-platelet-NK cell interaction focusing on metastatic tumor spread and discuss the molecular mechanisms underlying this trilateral crosstalk. Multivariate Cox regression models showed that SIRI was significantly associated with overall-survival (OS), cancer-specific survival (CSS), and metastatic-free survival (MFS), and PLR significantly affected OS and CSS (all P < 0.05). Inflammation has been shown to be a factor in tumorigenesis. ... (pdf) 28. Activated platelets can also provide negatively-charged surfaces that harbor coagulation factors and markedly potentiate cell-based thrombin generation. Disease-free survival rates were significantly worse among patients with elevated PLR values than among those with lower PLR value (5-year survival, 81.6% vs. 90.7%, respectively; P < 0.05). 1 part • 2 pages • 03:06 • Feb 03, 2018 • 1,299 views • 38 favorites . Since platelets also, mediated by platelets is challenging. All figure content in this area was uploaded by Hans-Georg Kopp, Department of Hematology/Oncology; Eberhard Karls University; Tuebingen, Germany. A wolf would like to catch a sheep for its supper but is finding it difficult to do so. Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target? 0000050623 00000 n This study aimed to evaluate the preoperative prognostic value of systemic inflammation response index and platelet-to-lymphocyte ratio (SIRI-PLR) in patients with upper tract urothelial carcinoma (UTUC). Operations were begun in the Edwards Plateau, the largest area of sheep concentration. A single moment of someone calling him a hero. Retrospective analysis of patients who underwent surgery for colorectal cancer with synchronous CRLM at the Division of General and Hepatobiliary Surgery, University of Verona Hospital Trust between 2005 and 2016. Wolf In Sheep's Clothing Composed by Set It Off • Digital Sheet music • 7 scores Wolf in Sheep's Clothing Cover. 0000040071 00000 n J Clin Invest, 1988; 81:1012-9; PMID:3280598; http://dx.doi.org/, NK cells in immunotherapy of human cancer. 1 part • 3 pages • 03:09 • Jun 07, 2017 • 1,151 views • 52 favorites. It's best to listen to the song first, to know the timing. 0000012385 00000 n Platelets are small anucleate blood cells generated from megakaryocytes in the bone marrow and cleared in the reticuloendothelial system. 0000040485 00000 n Download » Wolf in Sheep s Clothing. In 1950, there were 33 counties covering nearly 24,000,000 acres, which were considered to be coyote free (Fig. Now, the only way the former Lord of Calamity can achieve her goals is to play along with the rest of the sheep. You can read The Brigade A Wolf In Sheeps Clothing PDF direct on your mobile phones or PC. In multivariate analysis, elevated PLR, nuclear grade, and lymph node involvement were significant prognostic factors for disease-free survival in patients with breast carcinoma (P < 0.05). A Wolf in Sheep’s Clothing? This story is not very uplifting or does not have the … Methods Cancer Res 2011; 72:440-8; PMID: 22127925; http://dx.doi.org/10.1158/0008-5472. Notes: . The film airs at 10 p.m. The impaired NK cell reactivity was not due to induction of apoptosis but mediated by down-regulation of the activating immunoreceptor natural killer group 2, member D (NKG2D) on NK cells by platelet-derived transforming growth factor beta (TGF-beta). Capitec: A wolf in sheep’s clothing Based on our research and due diligence, we believe that Capitec is a loan shark with massively understated defaults masquerading as a community microfinance provider. Cancer Res 2009; 69:7775-83; PMID:19738039; http://dx.doi.org/10.1158/0008-5472.CAN-09-2123, of adhesive proteins in platelet tumor interaction in, vitro and metastasis formation in vivo. That's all it took for him. Platelets are small, anucleate, versatile blood cells that are generated by megakaryocytes in the bone marrow. The Example of Natural Killer Cells, Zitvogel L, Tesniere A, Kroemer GCancer despite immunosurveillance: immunoselection and immunosubversion. impeded by platelets. However, the person speaking had an ulterior motive. Izuku's life had changed when someone finally told him those words. Platelets are anucleate cells that are crucial mediators of haemostasis. The capability of tumor cells to induce platelet aggregation, on the other hand, correlates with their enhanced metastatic potential. Using ME Small Polyps of the Colon: The Wolf in Sheep’s Clothing with CE more than 90% of adenomatous polyps can be identified in vivo. memory. While we may not have a brick and mortar store on Jermyn Street in London, we have been manufacturing luxury tailored men's shirts for over a decade. A Wolf in Sheeps Clothing 84K Reads 2.2K Votes 38 Part Story. 4). SHEEP'S CLOTHING By Tracey Hammett Mr Wolf dreamt of eating a nice woolly sheep for his supper…but he just couldn W catch one. Beyond this secretion of various growth factors and cytokines/chemokines, platelets may also influence NK cell function by immunoregulatory molecules expressed on the platelet surface. The crossword clue possible answer is available in 5 letters.This answers first letter of which starts with F and can be found at the end of E. ET, Saturday, Oct. 17, and will be preceded at 8:30 p.m. Natural killer (NK) cells play an important role in cancer immunosurveillance and may prevent tumor progression and metastasis due to their ability to mediate direct cellular cytotoxicity and by releasing immunoregulatory cytokines, which shape adaptive immune responses. The wolf in sheep’s clothing.pdf. These numbers are down in both actual numbers and as a percent of the national flocks. Instant access to millions of titles from Our Library and it’s FREE to try! In mice, thrombocytopenia inhibits metastasis, and this is reversed by NK cell depletion, suggesting that platelets are an important additional player in NK cell-tumor interaction. Wolf in Sheep’s Clothing. Multivariate analyses identified multiple tumors, node invasion and high SII level as independent risk factors for OS, while multiple tumors, node invasion and high SII level were identified as independent risk factors for RFS. Appearances are deceptive. Platelets promote metastasis by protecting disseminating tumor cells from NK cell immunosurveillance, but the underlying mechanisms are not well understood. Results: Difficulty: novice. Following is the list of ID Codes for the song Wolf In Sheep’s Clothing. However, the knowledge about the molecular mechanisms by which platelets influence NK cells is fragmentary at best. Background: 0000040168 00000 n However, it is becoming increasingly clear that platelets have inflammatory functions and can influence both innate and adaptive immune responses. A wolf in sheep's clothing is symbolic for someone who outwardly looks harmless and kind with good intentions but inwardly is full of hate, evil and deceit. Moreover, it has been shown that metastasizing tumor cells do not travel through the blood alone but are rapidly coated by platelets. Conclusions: SII-PNI was a strong independent predictor of UTUC patients after RNU. The relevance of the song already sorts these songs. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic But one day it found the skin of a sheep that had been flayed and thrown aside, so it put it on over its own pelt and strolled down among the sheep. 0000040431 00000 n — The proposed transportation bill was a wolf in sheep's clothing, hiding wasteful projects such as a $400 million bridge that would only benefit a few people. A Wolf experienced great difficulty in getting at the sheep owing to the vigilance of the shepherd and his loyal dogs. Elevated SII level was an independent risk factor for OS and RFS in patients with ICC after hepatectomy. Download A Wolf In Sheep S Clothing PDF/ePub, Mobi eBooks by Click Download or Read Online button. With Jim Morlino, Olivia Adams, Audrey Battista, Ron Cavalier. The most popular version of this song is indeed a Nightcore remake, but you can find all other versions here as well. Author: Charlie Adhara. Blood coagulation, which is initiated by the intrinsic or extrinsic coagulation cascades, is the second wave of hemostasis. 0000002453 00000 n The role of platelet-derived "pseudo-self" in tumor immune evasion. If you have any other question or need extra help, please feel free to … In Sheep’s Clothing is Dr. Simon’s first book and has enjoyed unprecedented bestseller status for almost 14 years. There are, however, tumor cells that metastasize despite the presence of an intact NK system. Available in PDF, EPUB, and Mobi Format. The clinical implications of these basic science and translational research findings will also be discussed. (B) MHC Class I downregulation enables escape from T cell immunity but renders tumor cells susceptible to NK "missing self" recognition. Annals of The Royal College of Surgeons of England. 0000004355 00000 n Wolf In Sheep's Clothing Composed by Set It Off • Digital Sheet music • 7 scores Wolf in Sheep's Clothing Cover. The purpose of this study was to evaluate the prognostic role of thrombocytosis in patients with synchronous colorectal liver metastases (CRLM). https://www.researchgate.net/publication/282425069_A_wolf_in_sheep's_clothing In vivo, polyclonal monospecific anti-mouse von Willebrand factor antibody inhibited pulmonary metastases induced by CT26 tumor cells by 53-64%, B16a amelanotic melanoma cells by 45% and T241 Lewis bladder cells by 46% without induction of thrombocytopenia. —USA TODAY on The Wolf at the Door Agent Cooper Dayton and his partner, Oliver Park, are going undercover—at a retreat for couples who need counseling. Thus, platelets appear to contribute to metastases by their adhesive interaction with tumor cells via the adhesive proteins fibronectin and von Willebrand factor. with dendritic cells or monocytes/macrophages is well characterized, knowledge regarding their crosstalk with platelets, another central component of the blood, is still fragmentary. 0000005587 00000 n Platelets facilitate tumor progression and metastasis, In the early 1900s, organized predator control was initiated to remove coyotes and wolves from the sheep- and goat-producing areas of Texas. Displaying top 8 worksheets found for - The Wolf In Sheeps Clothing. This indicates that other unidentified platelet ligands may play important roles in thrombosis and might be novel antithrombotic targets. Search for: Recent Posts . At the site of vascular injury, platelet adhesion, activation, and aggregation constitute the first wave of hemostasis. the functional borders between these two arms of the immune response. 00: 59: 53. The wolf lived near a farm. The Edwards Plateau and, to a lesser extent, portions of other adjoining ecological areas presently account for 18% (1.2 million head) of the sheep and lambs and 85% (1.2. Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic function that provide host defence against microbial infection and tumours. Thus, platelets may contribute to all three waves of hemostasis and are central players in this critical physiological process to prevent bleeding. 9 0 obj <> endobj xref 9 42 0000000016 00000 n A Wolf In Sheep's Clothing. wolf in sheeps clothing a person or thing that appears harmless but is actually dangerous or bad dont trust dana shes a wolf in sheeps clothing who will try to steal your position if given the chance the politician portrayed himself as moderate but turned out to be a wolf in sheeps clothing with a radical agenda see also clothing wolf in. The next day, dressed in the skin, the Wolf strolled into the pasture with the Sheep. More from this series. ISSN: 0048-3486. Much later, the idiom has been applied by zoologists to varying kinds of predatory behaviour. Validation cohort confirmed the findings of derivation cohort. https://www.researchgate.net/publication/228106557_The_wolf_in_sheep's_clothing J Innate. Natural killer (NK) cells are cytotoxic lymphocytes that play an important role in tumor immunosurveillance, preferentially eliminating targets with low or absent expression of MHC class I and stress-induced expression of ligands for activating NK receptors. Thus, our data elucidate the molecular basis of the previously described influence of platelets on NK cell antitumor reactivity and suggest that therapeutic intervention in tumor cell-platelet interaction and the resulting TGF-beta release by platelets may serve to enhance antitumor immunity. 25 November, 2020. Join ResearchGate to find the people and research you need to help your work. Download » Traces police efforts in locating the Oakland County, Michigan child murderer . Download and print in PDF or MIDI free sheet music for Wolf In Sheeps Clothing by Set It Off arranged by XENDRAENYX for Piano (Solo)
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